CENPB ELISA Kit for Human(Homo sapiens) | EIAab.comCENPB ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CENPB(Gene name) > Human

CENPB (Gene name),

Major centromere autoantigen B (Protein name ), CENPB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CENPB;

Protein name:

Major centromere autoantigen B;

Alternative:

Centromere protein B(CENP-B);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with CENPT.

Function:

Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.

Subcellular Location:

Nucleus Chromosome centromere

Protein Attributes:

Sequence length:

599

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

599:

FAMVKRYLTS | FPIDDRVQSH | ILHLEHDLVH | VTRKNHARQA | GVRGLGHQS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.516855

SMR:

P07199

STRING:

9606.ENSP00000369075

MIM:

117140

String:

P07199

KEGG:

hsa:1059

Pfam:

PF09026

Uniprot:

P07199

FOR

ELISA Kit for Human Major centromere autoantigen B

Cat.:

E1125h

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96T

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ELISA Kit for Human Major centromere autoantigen B

Cat.:

E1125m

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Manual:

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96T

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CLIA Kit for Human Major centromere autoantigen B

Cat.:

U1125m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Major centromere autoantigen B

Cat.:

U1125h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Major centromere autoantigen B

Cat.:

P1125Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Major centromere autoantigen B

Cat.:

P1125Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Major centromere autoantigen B

Protein for Human Major centromere autoantigen B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins."
Sullivan K.F. , Glass C.A.
Chromosoma100:360-370(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Uterus.
4.

"Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen."
Earnshaw W.C. , Sullivan K.F. , Machlin P.S. , Cooke C.A. , Kaiser D.A. , Pollard T.D. , Rothfield N.F. , Cleveland D.W.
J. Cell Biol.104:817-829(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-599
5.

"A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity."
Yoda K. , Kitagawa K. , Masumoto H. , Muro Y. , Okazaki T.
J. Cell Biol.119:1413-1427(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;DOMAINS
6.

"Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells."
Orthaus S. , Biskup C. , Hoffmann B. , Hoischen C. , Ohndorf S. , Benndorf K. , Diekmann S.
ChemBioChem9:77-92(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B."
Hellwig D. , Muench S. , Orthaus S. , Hoischen C. , Hemmerich P. , Diekmann S.
J. Biophotonics1:245-254(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CENPT
8.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-165 AND THR-398;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Identification of novel alpha-n-methylation of CENP-B that regulates its binding to the centromeric DNA."
Dai X. , Otake K. , You C. , Cai Q. , Wang Z. , Masumoto H. , Wang Y.
J. Proteome Res.12:4167-4175(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE OF INITIATOR METHIONINE;METHYLATION AT GLY-2;MUTAGENESIS OF LYS-4
12.

"A helix-turn-helix structure unit in human centromere protein B (CENP-B)."
Iwahara J. , Kigawa T. , Kitagawa K. , Masumoto H. , Okazaki T. , Yokoyama S.
EMBO J.17:827-837(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-56
13.

"Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA."
Tanaka Y. , Nureki O. , Kurumizaka H. , Fukai S. , Kawaguchi S. , Ikuta M. , Iwahara J. , Okazaki T. , Yokoyama S.
EMBO J.20:6612-6618(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-129 IN COMPLEX WITH DNA;H-T-H MOTIF
14.

"Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution."
Tawaramoto M.S. , Park S.Y. , Tanaka Y. , Nureki O. , Kurumizaka H. , Yokoyama S.
J. Biol. Chem.278:51454-51461(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 536-599;SUBUNIT

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